Functional Probe Research Laboratory　Team Leader：Hisashi Doi
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Publications

H. Doi, I. Ban, A. Nonoyama, K. Sumi, C. Kuang, T. Hosoya, H. Tsukada, M. Suzuki,
Palladium(0)-Mediated Rapid Methylation and Fluoromethylation on Carbon Frameworks by Reacting Methyl and Fluoromethyl Iodide with Aryl and Alkenyl Boronic Acid Esters Useful for the Synthesis of C—11CH3– and C—18FCH2–Containing PET Tracers
Chem. Eur. J. (2009), 15(16):4165-71.
J. Barletta, F. Karimi, H. Doi, B. Långström,
Synthesis of diethyl [carbonyl-11C]malonate from [11C]carbon monoxide by rhodium-promoted carbonylation and its application as a reaction intermediate
J. Label. Compd. Radiopharm. 49, 801-809 (2006).
T. Hosoya, K. Sumi, H. Doi, M. Wakao, and M. Suzuki,
Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene
Org. Biomol. Chem., 4, 410-415 (2006).
H. Doi, J. Barletta, M. Suzuki, R. Noyori, Y. Watanabe, B.Långström,
Synthesis of 11C-labelled N,N’-diphenylurea and ethyl phenylcarbamate by a rhodium-promoted carbonylation via [11C]isocyanatobenzene using phenyl azide and [11C]carbon monoxide
Org. Biomol. Chem., 2, 3063-3066 (2004).
M. Suzuki, H. Doi, T. Hosoya, B.Långström, Y. Watanabe,
Rapid methylation on carbon frameworks leading to the synthesis of a PET tracer capable of imaging a novel CNS-type prostacyclin receptor in living human brain
Trends Anal. Chem., 23, 595-607 (2004).
T. Hosoya, M. Wakao, Y. Kondo, H. Doi, M. Suzuki,
Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with 1-propynyl group
Org. Biomol. Chem., 2, 24-27 (2004).
M. Suzuki, H. Doi, K. Kato, M. Björkman, B. Långström, Y. Watanabe, R. Noyori,
Rapid Methylation for the Synthesis of a 11C-Labeled Tolylisocarbacyclin Imaging the IP2 Receptor in a Living Human Brain Tetrahedron, 56, 8263-8273 (2000).
M. Björkman, H. Doi, B. Resul, M. Suzuki, R. Noyori, Y. Watanabe, B.Långström,
Synthesis of a 11C-Labelled Prostaglandin F2α Analogue Using an Improved Method for Stille Reactions with [11C]Methyl iodide
J. Labelled Compd. Radiopharm., 43, 1327-1334 (2000).
M. Björkman, Y. Andersson, H. Doi, K. Kato, M. Suzuki, R. Noyori, Y. Watanabe, B. Långström,
Synthesis of 11C/13C-labelled Prostacyclins
Acta Chem. Scand., 52, 635-640 (1998).
M. Suzuki, H. Doi, M. Björkman, Y. Andersson, B. Långström, Y. Watanabe, R. Noyori,
Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Synthesis of 11CH3-Labeled PET Tracers
Chem. Eur. J., 3, 2039-2042 (1997).

Conference Presentations

2008.2
Pd(0)-Mediated Rapid C-Methylations for the Synthesis of 11C-Incorporated PET Tracers
(International Conference on Drug Design & Discovery, Dubai, UAE, Feb 4-7)
2000.12
Realization of high coupling efficiency in the rapid Stille methylation for the synthesis of 11C-labeled tolylisocarbacyclins toward the in vivo investigation of a IP2 receptor in a human brain
(2000 International Chemical Congress of Pacific Basin Societies [PACIFICHEM 2000], December15, Hawaii, USA)

Honors and Awards

2007
The 44th Erwin von Bälz Prize, First Prize