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Functional Probe Research Laboratory Team Leader:Hirotaka Onoe

[Applications of molecular imaging technology to regenerative medicine]

Regenerative medicine includes rehabilitation, cell grafting, approches utilizing gene transfer, and engineering approaches utilizing artificial materials. To improve the yield of these regenerative medical techniques and to construct valid methodologies, it will be required optimization of longitudinal with respect to functionality, targeted migration, and fate of engrafted cells and regenerative materials. For clinical applications, we have to further develop technology for quantitative visualization during the functional recovery process in regenerative therapy. In CMIS, mainly using primates as an animal model, we are trying to apply sophisticated molecular imaging techniques for the monitoring of model animals and human recipients of regenerative medical treatment, with the goal of integrating advanced research in regenerative medicine.

[Use of PET molecular imaging for genetically modified mice and small non-human primates]

In recent years, dramatic advance in biological genetic engineering have facilitated attempts to use genetically modified animals in basic research and in drug development, and an important role for molecular imaging is developing in research using small animals. We utilize PET molecular imaging technique in a wide range of research, from basic life science research to applied research with the aim of supporting drug discovery, and we construct a research system capable of dealing with a variety of animals, from mice which are easily genetically modified to monkeys which possess higher brain function. We are also trying to apply molecular imaging techniques on animal models for various diseases with the aim of elucidating pathogenic mechanisms and determining therapeutic efficacy.

January 29, 2013
New research uncovers the neural mechanism underlying drug cravings
April 19,2010
Fluorescent labeling of living cells easily accomplished in only minutes using chemical reactions
May 20, 2010
Cancer recognition capability improved with technique to chemically inject glycan links into lymphocytes
April 19,2010
Fluorescent labeling of living cells easily accomplished in only minutes using chemical reactions
March 09,2010
Labeling of antipyretic and analgesic drugs enables successful visualization inside the body
December 7, 2012
Imaging of marmoset brains provides an insight into the brain regions involved in regulating social behavior
September 30, 2011
Imaging inflammation in the living brain
A molecular probe that targets a pro-inflammatory enzyme allows visualization of inflammation during brain injury in rats
September 09, 2011
Protecting young minds
A Popular flu medication's neurologic side effects in children may be the result of inefficient drug
June 11, 2010
Projecting pain relief
Radioactively labeled drugs can track inflammation inthe brain
March 07, 2008
Brain repairs
Healing from spinal cord injury requires use of different regions of the brain
[Contact information for research-related enquiries]
Hirotaka Onoe TEL : 078-304-7120 Mail 
[Contact information for non-research-related enquiries]
Yoshiko Hirano TEL : 078-304-7121 Mail