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[Molecular Probe Dynamics Laboratory]
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Main papers published

Mizuno, K., Tanaka, M., Fukuda, S., Imai-Matsumura, K., and Watanabe, Y.
Relationship between cognitive functions and prevalence of fatigue in elementary and junior high school students
Brain Dev., in press (2010)
Mizuno, K., Tanaka, M., Fukuda, S., Sasabe, T., Imai-Matsumura, K., and Watanabe, Y.
Changes in cognitive functions of students in the transitional period from elementary school to junior high school
Brain Dev., in press (2010)
Mizuno, K., Tanaka, M., Tajima, K., Okada, N., Rokushima, K., and Watanbe, Y.
Effects of mild-stream bathing on recovery from mental fatigue
Med. Sci. Monit., 16, CR8-CR14 (2010)
Tanaka, M., Mizuno, K., Fukuda, S., and Watanabe, Y.
Personality and fatigue in medical students
Psychol. Rep., 106, 567-575 (2010)
Takashima T, Nagata H, Nakae T, Cui Y, Wada Y, Kitamura S, Doi H, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
PET studies using 15R-[11C] TIC-Me for the evaluation of hepatobiliary transport.
J Pharmacol Exp Ther.2010 Nov;335(2):314-23.
Kamei, N., Morishita, M., Kanayama, Y., Hasegawa, K., Nishimura, M., Hayashinaka, E., Wada, Y., Watanabe, Y., and Takayama, K.
Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography.
Journal of Controlled Release. 146(1), 16-22, (2010)
Tanaka K, Minami K, Tahara T, Fujii Y, Siwu ER, Nozaki S, Onoe H, Yokoi S, Koyama K, Watanabe Y, Fukase K.
Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking.
ChemMedChem. ;5(6), 841-5 (2010)
Nozaki S, Mizuma H, Tanaka M, Jin G, Tahara T, Mizuno K, Yamato M, Okuyama K, Eguchi A, Akimoto K, Kitayoshi T, Mochizuki-Oda N, Kataoka Y, Watanabe Y.
Thiamine tetrahydrofurfuryl disulfide improves energy metabolism and physical performance during physical-fatigue loading in rats.
Nutr Res. ;29(12), 867-72 (2009)
Nozaki S, Tanaka M, Mizuno K, Ataka S, Mizuma H, Tahara T, Sugino T, Shirai T, Eguchi A, Okuyama K, Yoshida K, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y.
Mental and physical fatigue-related biochemical alterations.
Nutrition. ;25(1), 51-57 (2009)
Tanaka, M., Mizuno, K., Tajima, S., Sasabe, T., and Watanabe, Y.
Central nervous system fatigue alters autonomic nerve activity
Life Sci., 84, 235-239 (2009)
Tanaka, M., Mizuno, K., Fukuda, S., Shigihara, Y., Tajima, S., and Watanabe, Y.
Personality traits associated with intrinsic academic motivation in medical students
Med. Educ., 43, 384-387 (2009)
Mizuno, K., Tanaka, M., Ishii, A., Tanabe, C.H., Onoe, H., Sadato, N., and Watanabe, Y.
The neural basis of academic achievement motivation
NeuroImage, 42, 369-378 (2008)
Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y.
Antifatigue effects of coenzyme Q10 during physical fatigue
Nutrition, 24, 293-299 (2008)
Hasegawa, K., Kanayama, Y., Nishimura, M., Sako, T., Wada, Y., and Watanabe, Y.
A facile method for solid-phase conjugation of peptide with unprotected DOTA and synthesis of 68Ga-DOTA-somatostatin.
Peptide Science, 45th, 417-418, (2008).
Takahashi, K., Tamura, Y., Watanabe, Y., Långström, B., and Bergström, M.
Alteration in [11C]vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide.
Neuroreport, 19(4): 431-435, 2008
Matsumoto K., Yamamoto S., Wada Y., Shimizu K., Murase K., Senda M.
Reliability of plural measuring instruments for quantitative PET measurement -performance of dose-calibrator, auto well gamma counter, continuous blood sampling system, and PET scanner.
日本放射線技術学会誌 64, 1224-34(2008)
Cui, Y.L., Kataoka, Y., Inui, T., Mochizuki, T., Onoe, H., Matsumura, K., Urade, Y., Yamada, H. and Watanabe, Y.
Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats
J Neurosci Res, 86 929-936 (2007)
Tamura, Y., Kataoka, Y., Cui, Y.L., Takamori, Y., Watanabe, Y. and Yamada, H.
Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in adult rat cerebral cortex in vivo
Neuroscience, 148, 535-540 (2007)
Takahashi K, Hallberg M, Magnusson K, Nyberg F, Watanabe Y, Långström B, and Bergström M.
[11C]Vorozole binding to aromatase in AAS-treated rats
NeuroReport, 18, 171-74 (2007)
Motomura, S., Enomoto, S., Haba, H., Igarashi, K., Gono, Y., and Yano, Y.
Gamma-Ray Compton Imaging of Multitracer in Biological Samples Using Strip Germanium Telescope
IEEE Transactions on Nuclear Science, 54, 710-717 (2007)
Cui, Y.L., Takamatsu, H., Kakiuchi, T., Ohba, H., Kataoka, Y., Yokoyama, C., Onoe, H., Watanabe, Yu., Hosoya, T., Suzuki, M., Noyori, R., Tsukada, H., and Watanabe, Y.
Neuroprotection by a central nervous system-type prostacyclin receptor ligand demonstrated in monkeys subjected to middle cerebral artery occulusion and reperfusion: A positron emission tomography study
Stroke, 37, 2830-2836 (2006)
Kondo, S., Hosono, M.N., Wada, Y., Ishii, K., Matsumura, A., Takada, Y., Tashiro, M., Okamura, T., Fukuda, H., Yamada, R., Watanabe, Y., and Inoue, Y.
Use of FDG-microPET for detection of small nodules in a rabbit model of pulmonary metastatic cancer
Ann. Nucl. Med. 18, 51-57 (2004)
Yamamoto, S., Ouchi, Y., Onoe, H., Yoshikawa, E., Tsukada, H., Takahashi, H., Iwase, M., Yamaguti, K., Kuratsune, H., and Watanabe, Y.
Reduction of serotonin transporters of patients with chronic fatigue syndrome
Neuroreport 15, 2571-2574 (2004)
Matsumura, A., Mizokawa, S., Tanaka, M., Wada, Y., Nozaki, S., Nakamura, F., Shiomi, S., Ochi, H., and Watanabe, Y
Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: Comparison between quantitative data obtained with microPET and ex vivo autoradiography
NeuroImage 20, 2040-2050 (2003)
Kuratsune, H., Yamaguti, K., Lindh, G., Evengård , B., Hagberg, G., Matsumura, K., Iwase, M., Onoe, H., Machii, T., Kanakura, Y., Kitani, T., Långström , B., and Watanabe, Y.
Brain regions involved in fatigue sensation: Reduced acetylcarnitine uptake into the brain
NeuroImage 17, 1256-1265 (2002)
Enblad, P., Frykholm, P., Valtysson, J., Silander, H.C., Andersson, J., Fasth, K.J., Watanabe, Y., Långström, B., Hilleled, L., and Persson, L.
Middle cerebral artery occlusion and reperfusion in primates monitored by microdialysis and sequential positron emission tomography
Stroke 32, 1574-1580 (2001)

Conference Presentations

2010
Excessive neural activation during divided attention processing in childhood chronic fatigue syndrome American Academy of Children & Adolescent Psychiatry (AACAP) 57th Annual Meeting, New York, Oct 26-31
2010
Development of iterative reconstruction algorithm incorporating transaxial distance-dependent resolution compensation for small animal PET. Annual Congress of the European Association of Nuclear Medicine, Vienna, Austria, Oct 9-13
2010
Developmental Changes in P-glycoprotein Function at the Blood-Brain Barrier of Non-Human Primates: PET Study with R-[11C]Verapamil. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
Evaluation of gastrointestinal drug absorption process after oral administration using positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and its rate limiting steps under anesthesia. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
64Cu-labeling of octreotide utilizing the N-terminal Cu binding motif (ATCUN). 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
In vivo monitoring of experimental arthritis using [11C]PK11195 and [11C]Ketoprofen before joint destruction. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
11C-Labeled cetrozole and its analogs: Excellent PET probes for aromatase. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
Detecting atherosclerotic plaques using PET and CT targeted p-selectin in mice. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
Evaluation of Serotonin Dynamics in the Brain of Functional Somatic Syndrome using Positron Emission Tomography. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
Amyloid plaque detection by using clinical magnetic field strength MRI. 2010 World Molecular Imaging Congress, Kyoto, Japan, Sep 8-11
2010
Evaluation of in vivo hepatobiliary transport using positron emittion tomography (PET): Studies in rats and application to microdosing clinical studies, International Society for the Study of Xenobiotics, Istanbul, Turkey, Sep 4-8
2009
PET・SPECTを用いた実験データ解析
2009
小動物PETを用いた機能イメージング
2008
PET studies on the evaluation of multidrug resistance-associated protein 2 function in bliliary excreation.
2008
Evaluation of sub-second duration dynamic PET images of mice.
2008
Anabolic-androgenic steroid increases [11C]vorozole binding to aromatase in neurons of the hypothalamus in rat and rhesus monkey.
2008
固相上での簡便な無保護DOTAのペプチドへの修飾法と68Ga-DOTA-somatostatinの合成
2007
Aromatase level altered by treatment of anabolic androgenic steroids is regulated through androgen receptor.
2007
Attenuation effect of a rat for PET scanning.
2006
A simple labeling method with Ga-68 for PET molecular imaging on peptides and proteins.
2006
Evaluation and optimization of 3D MAP image reconstruction for microPET P4.

Honors and Awards

2008
Award of Osaka city Mayor
2007
The 44th Erwin von Bälz Prize, First Prize