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Functional Probe Research Laboratory Team Leader：Hirotaka Onoe
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Main papers published

Imamura, K., Onoe, H., Shimazawa, M., Nozaki, S., Wada, Y., Kato, K., Nakajima, H., Mizuma, H., Onoe, K., Taniguchi, T., Sasaoka, M., Hara, H., Tanaka, S., Araie, M., Watanabe, Y.
Molecular imaging reveals unique degenerative changes in experimental glaucoma.
Neuroreport, 28;20(2):139-44, 2009.
Mizuno, K., Tanaka, M., Ishii, A., Tanabe, HC., Onoe, H., Sadato, N., Watanabe, Y.
The neural basis of academic achievement motivation.
Neuroimage, 1;42(1):369-78, 2008.
Nishimura, Y., Onoe, H., Morichika, Y., Perfiliev, S., Tsukada, H., Isa, T.
Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.
Science, 318(5853):1150-5, 2007.
Sato, A., Nishimura, Y., Oishi, T., Higo, N., Murata, Y., Onoe, H., Saito, K., Tsuboi, F., Takahashi, M., Isa, T., Kojima, T.
Differentially expressed genes among motor and prefrontal areas of macaque neocortex.
Biochem Biophys Res Commun, 362 (3):665-9, 2007.
Nishimura, Y., Onoe, H., Morichika, Y., Tsukada, H., Isa, T.
Activation of parieto-frontal stream during reaching and grasping studied by positron emission tomography in monkeys.
Nuerosci Res, 59 (3):243-50, 2007.
Kojima, T., Onoe, H., Hikosaka, K., Tsutsui, K., Tsukada, H., Watanabe, M.
Domain-related differentiation of working memory in the Japanese macaque (Macaca fuscata) frontal cortex: a positron emission tomography study.
Eur J Neurosci, 25(8):2523-35, 2007.
Tahara, T., Tanaka, M., Nozaki, S., Jin, G., Onoe, H., Watanabe, Y.
Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue.
Biochem Biophys Res Commun, 353:1068-73, 2007.
Cui, Y., Takamatsu, H., Kakiuchi, T., Ohba, H., Kataoka, Y., Yokoyama, C., Onoe, H., Watanabe, Y., Hosoya, T., Suzuki, M., Noyori, R., Tsukada, H., Watanabe, Y.
Neuroprotection by a Central Nervous System-Type Prostacyclin Receptor Ligand Demonstrated in Monkeys Subjected to Middle Cerebral Artery Occlusion and Reperfusion: A Positron Emission Tomography Study.
Stroke, 37: 2830-2836, 2006.
Yokoyama, C., Tsukada, H., Watanabe, Y., Onoe, H.
A dynamic shift of neural network activity before and after learning-set formation.
Cereb Cortex, 15: 796-801, 2005.

Conference Presentations

2008
Activation of microglia and reduction of cerebral glucose metabolism in a mouse model of fatigue caused by prolonged restless wakefulness.
2008
Genotype dependent antidepressant-like effect of green odor in mice.
2008
A novel method of PET imaging for neuropsychiatric disorders in mice.
2008
Change in behavioe and brain GABAergic activity by mental fatigue:PET study with macaque monkeys.
2008
Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue.
2008
Novel imaging tools for regenerative therapy with PET reporter transgenes. In vivo brain imaging of serotonin and dopamine transporters by micro PET with conscious mice, marmosets, and macaque monkeys.
2008
Establishment of a novel brain PET imaging method of mouse under conscious state.
2008
In vivo brain imaging of serotonin and dopamine transporters by microPET with conscious mice, marmosets, and macaque monkeys.
2008
Functional brain mapping in transverse patterning task; PET study with conscious monkeys.
2008
Characteristics of behavior and vocalization during a social challenge in common marmosets.

Honors and Awards

2012
Japanese Society for Molecular Imaging, Excellent Presentation Award (Toshiyuki Kawasaki)
2012
RIKEN Research and Technology Incentive Award (Hiroshi Mizuma)
2011
Japanese Society for Molecular Imaging, Excellent Presentation Award (Miho Shukuri)
2010
SNM 2010 Annual Meeting, Second Place Poster (Hiroshi Mizuma)
2007
The 44th Erwin von Bälz Prize, First Prize (Hirotaka Onoe)
1989
The 26th Erwin von Bälz Prize, First Prize (Hirotaka Onoe)

Press Release

May 20, 2010
Cancer recognition capability improved with technique to chemically inject glycan links into lymphocytes
April 19,2010
Fluorescent labeling of living cells easily accomplished in only minutes using chemical reactions
March 09,2010
Labeling of antipyretic and analgesic drugs enables successful visualization inside the body
November 16, 2007
The National Institute for Physiological Sciences and the Japan Science and Technology Agency, in collaboration with RIKEN and Hamamatsu Photonics K.K.'s Central Research Laboratory, have learned that after one to three months of rehabilitation training consisting of repetitively picking things up, Japanese macaque monkeys that had lost movement in their fingertips due to spinal injury start to move their fingertips as they did before the injury. The research also pinpointed the changes that occur during this process in the area of the brain related to the recovery.