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[Molecular Imaging Medicinal Chemistry Laboratory] Team Leader:Masaaki Suzuki
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Our laboratory aims to develop novel methodologies in in vivo molecular science necessary to the promotion of exploratory studies for drug candidates, particularly focusing on imaging the dynamic behavior of designed compounds in vital systems using positron emission tomography (PET). Some of our specific research goals include (1) the development of rapid chemical reactions, particularly rapid C-methylations through carbon-carbon bond formations to incorporate short-lived 11C radio-nuclides into organic molecules to elaborate metabolically stable PET tracers in addition to the 18F incorporation. (2) Design and synthesis of specific molecular probes for targeting important biological phenomena and serious diseases.(3) The application of the rapid reactions to the synthesis of high-definition PET tracers and (4) efficient chemical synthesis of highly polished drugs candidates.(5) Extensive collaboration with an instrument company to accurize and micronize the synthetic apparatuses and enhance safety. The novel method of methylation offers a number of benefits. The C-11CH3 bond is metabolically highly stable, thus the resulting image is very reliable. As well, the methyl group possesses the minimum carbon substituent and is non-polar, allowing high variation from the lead compound with minimal change in functions (bioactivities), permitting tracer design within a predictable range.