[Molecular Imaging Medicinal Chemistry Laboratory] Team Leader:Masaaki Suzuki
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publications

Main papers published

J.Ymamada, M.Muraki, N.Kataoka, T.Hosyoya, M.Suzuki, M.Hagiwara, H.Kimura
Combination of CIK Family Kinase and SRp75 Modulates Alternative Splicing of Adenovirus E1A
Genes to Cells, 13(3), 233-244 (2008).
M. Soen, T. Minami, S. Tatsumi, T. Mabuchi, K. Furuta, M. Maeda, M. Suzuki, S. Ito
A Synthetic Kainoid, (2S,3R,4R) -3-Carboxymethyl-4- (Phenylthio) Pyrrolidine-2-Carboxylic Acid (PSPA-1) Serves as a NovelAnti-Allodynic Agent for Neuropathic Pain
European Journal of Pharmacology, 575, 75-81 (2007).
T.Satoh, S.-i. Okamoto, J. Cui, Y. Watanabe, K. Furuta, M. Suzuki, K. Tohyama
Activation of the Keap1/Nrf2 Pathway for Neuroprotection by Electrophilic Phase II Inducers
Proc. Natl. Acad. Sci. U.S.A., 103, 768-773 (2006).
T.Hosoya, K. Sumi, H. Doi, M. Wakao, M. Suzuki
Rapid Methylation on Carbon Frameworks Useful for the Synthesis of 11CH3-Incorporated PET Tracers : Pd(0)-Mediated Rapid Coupling of Methyl Iodide with an Alkenyltributylstannane Leading to a 1-MethylalkeneOrg. Biomol.
Chem., 4, 410-415 (2006).
T. Hosoya, T. Hiramatsu, T. Ikemoto, M. Nakanishi, H. Aoyama, A. Hosoya, T. Iwata, K. Maruyama, M. Endo, M. Suzuki
Novel Bifunctional Probe For Radioisotope-Free Photoaffinity Labeling: Compact Structure Comprised of Photospecific Ligand Ligation and Detectable Tag Anchoring Units Org. Biomol.
Chem., 2(5), 637-641 (2004).
M. Muraki, B. Ohkawara, T. Hosoya, H. Onogi, J. Koizumi, T. Koizumi, K. Sumi, J. Yomoda, M. V. Murray, H. Kimura, K. Furuichi, H. Shibuya, A. R. Krainer, M. Suzuki, M. Hagiwara
Manipulation of Alternative Splicing by a Newly Developed Inhibitor of Clks
J. Biol. Chem., 279, 24246-24254 (2004).
M. Suzuki, H. Doi, T. Hosoya, B. Langstrom, Y. Watanabe
Rapid Methylation on Carbon Frameworks Leading to the Synthesis of a PET Tracer Capable of Imaging a Novel CNS-Type Prostacyclin Receptor in Living Human Brain
Trends in Analytical Chemistry, 23, 595-607 (2004).
M. Suzuki, H. Koyama, R. Noyori
Effects of HMPA on the Structure and Reactivity of the Lithium Enolate of Cyclopentanone: The Dimer is Responsible for Alkylation and Proton Exchange Reactions
Bull. Chem. Soc. Jpn., 77(2), 259-268 (2004).
Y. Sasaki, M. Ikenoya, N. Yamamoto, M. Suzuki, H. Hidaka
Novel and Specific Rho-Kinase Inhibitor, H1152, Directed Against the Rho-Kinase Involved Pathway
Cell. Molecular Biology Letters, 6, 506 (2001).
K. Furuta, K. Tomokiyo, T. Satoh, Y. Watanabe, M. Suzuki
Designed Prostaglandins with Neurotrophic Activities
Chem Bio Chem., 1, 283-286 (2000).
M. Suzuki, R. Noyori, B. Langstrom, Y. Watanabe
Molecular Design of Prostaglandin Probes in Brain Research: High, Specific Binding to a Novel Prostacyclin Receptor in the Central Nervous System
Bull. Chem. Soc. Jpn., 73, 1053-1070 (2000).
M. Suzuki, H. Doi, M. Bjorkman, Y. Andersson, B. Langstrom, Y. Watanabe, and R. Noyori
Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Systhesis of 11CH3-Labeled PET Tracers
Chem. Eur. J, 3, 2039-2042 (1997)
M. Suzuki, K. Kato, R. Noyori, Yu. Watanabe, H. Takechi, K. Matsumura, B. Langstrom , and Y. Watanabe
(15R)-16-m-Tolyl-17,18,19,20-tetranorisocarbacyclin: A Stable Ligand with High Binding Affinity and specificity for a Prostacyclin Receptor in the Central Nervous System
Angew. Chem., Int. Ed. Engl., 35, 334-336 (1996).
R. Noyori and M. Suzuki
Organic Synthesis of the Prostaglandins: Advancing Biology
Science, 259, 44-45 (1993)
M. Suzuki, A. Yanagisawa, and R. Noyori
The Three-Component Coupling Synthesis of Prostaglandins
J. Am. Chem. Soc.,1988, 110 (14), pp 4718–4726
R. Noyori and M. Suzuki
Prostaglandin Synthesis by Three-Componennt Coupling
Angew. Chem., 96, 854-882 (1984); Angew. Chem., Int. Ed. Engl., 23, 847-876(1984)
R. Noyori, S. Murata, and M. Suzuki
Trimethylsilyl Triflate in Organic Synthesis
Tetrahedon(Tetrahedon Symposium-In-Print,E. J. Corey,Ed.) 37, 3899-3910(1981)

Conference Presentation

2008
An Efficient,General Synthesis of 11C-and 18F-incorporated PET Tracers Toward Revolutionizing Drug Development and Diagnosis
(1st International Conference on Drug Design & Discovery [Dubai,Febraury 7,2008], Invited lecture.)

Honors and Awards

2007
The 44th Erwin von Baelz Prize
2004
The BCSJ Award
2000
The Chemical Society of Japan Award for Creative Work
1981
The Chemical Society of Japan Award for Young Chemists