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分子イメージング創薬化学研究チーム[Molecular Imaging Medicinal Chemistry Laboratory] チームリーダー:鈴木 正昭



R. Noyori, S. Murata, and M. Suzuki
Trimethylsilyl Triflate in Organic Synthesis
Tetrahedon(Tetrahedon Symposium-In-Print,E. J. Corey,Ed.) 37, 3899-3910(1981)
R. Noyori and M. Suzuki
Prostaglandin Synthesis by Three-Componennt Coupling
Angew. Chem., 96, 854-882 (1984); Angew. Chem., Int. Ed. Engl., 23, 847-876(1984)
M. Suzuki, A. Yanagisawa, and R. Noyori
The Three-Component Coupling Synthesis of Prostaglandins
J. Am. Chem. Soc.
R. Noyori and M. Suzuki
Organic Synthesis of the Prostaglandins: Advancing Biology Science, 259, 44-45 (1993)
M. Suzuki, K. Kato, R. Noyori, Yu. Watanabe, H. Takechi, K. Matsumura, B. Långström , and Y. Watanabe
(15R)-16-m-Tolyl-17,18,19,20-tetranorisocarbacyclin: A Stable Ligand with High Binding Affinity and specificity for a Prostacyclin Receptor in the Central Nervous System
Angew. Chem., Int. Ed. Engl., 35, 334-336 (1996).
M. Suzuki, H. Doi, M. Björkman, Y. Andersson, B. Långström, Y. Watanabe, and R. Noyori
Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Systhesis of 11CH3-Labeled PET Tracers
Chem. Eur. J, 3, 2039-2042 (1997)
M. Suzuki, R. Noyori, B. Långström, Y. Watanabe
Molecular Design of Prostaglandin Probes in Brain Research: High, Specific Binding to a Novel Prostacyclin Receptor in the Central Nervous System
Bull. Chem. Soc. Jpn., 73, 1053-1070 (2000).
K. Furuta, K. Tomokiyo, T. Satoh, Y. Watanabe, M. Suzuki
Designed Prostaglandins with Neurotrophic Activities
Chem Bio Chem., 1, 283-286 (2000).
Y. Sasaki, M. Ikenoya, N. Yamamoto, M. Suzuki, H. Hidaka
Novel and Specific Rho-Kinase Inhibitor, H1152, Directed Against the Rho-Kinase Involved Pathway
Cell. Molecular Biology Letters, 6, 506 (2001).
M. Suzuki, H. Koyama, R. Noyori
Effects of HMPA on the Structure and Reactivity of the Lithium Enolate of Cyclopentanone: The Dimer is Responsible for Alkylation and Proton Exchange Reactions
Bull. Chem. Soc. Jpn., 77(2), 259-268 (2004).
T. Hosoya, T. Hiramatsu, T. Ikemoto, M. Nakanishi, H. Aoyama, A. Hosoya, T. Iwata, K. Maruyama, M. Endo, M. Suzuki
Novel Bifunctional Probe For Radioisotope-Free Photoaffinity Labeling: Compact Structure Comprised of Photospecific Ligand Ligation and Detectable Tag Anchoring Units Org. Biomol.
Chem., 2(5), 637-641 (2004).
M. Muraki, B. Ohkawara, T. Hosoya, H. Onogi, J. Koizumi, T. Koizumi, K. Sumi, J. Yomoda, M. V. Murray, H. Kimura, K. Furuichi, H. Shibuya, A. R. Krainer, M. Suzuki, M. Hagiwara
Manipulation of Alternative Splicing by a Newly Developed Inhibitor of Clks
J. Biol. Chem., 279, 24246-24254 (2004).
M. Suzuki, H. Doi, T. Hosoya, B. Långström, Y. Watanabe
Rapid Methylation on Carbon Frameworks Leading to the Synthesis of a PET Tracer Capable of Imaging a Novel CNS-Type Prostacyclin Receptor in Living Human Brain
Trends in Analytical Chemistry, 23, 595-607 (2004).
T.Hosoya, K. Sumi, H. Doi, M. Wakao, M. Suzuki
Rapid Methylation on Carbon Frameworks Useful for the Synthesis of 11CH3-Incorporated PET Tracers : Pd(0)-Mediated Rapid Coupling of Methyl Iodide with an Alkenyltributylstannane Leading to a 1-MethylalkeneOrg. Biomol.
Chem., 4, 410-415 (2006).
T.Satoh, S.-i. Okamoto, J. Cui, Y. Watanabe, K. Furuta, M. Suzuki, K. Tohyama
Activation of the Keap1/Nrf2 Pathway for Neuroprotection by Electrophilic Phase II Inducers
Proc. Natl. Acad. Sci. U.S.A., 103, 768-773 (2006).
M. Soen, T. Minami, S. Tatsumi, T. Mabuchi, K. Furuta, M. Maeda, M. Suzuki, S. Ito
A Synthetic Kainoid, (2S,3R,4R) -3-Carboxymethyl-4- (Phenylthio) Pyrrolidine-2-Carboxylic Acid (PSPA-1) Serves as a NovelAnti-Allodynic Agent for Neuropathic Pain
European Journal of Pharmacology, 575, 75-81 (2007).
J.Ymamada, M.Muraki, N.Kataoka, T.Hosyoya, M.Suzuki, M.Hagiwara, H.Kimura
Combination of CIK Family Kinase and SRp75 Modulates Alternative Splicing of Adenovirus E1A
Genes to Cells, 13(3), 233-244 (2008).


An Efficient,General Synthesis of 11C-and 18F-incorporated PET Tracers Toward Revolutionizing Drug Development and Diagnosis
(1st International Conference on Drug Design & Discovery [Dubai,Febraury 7,2008], 招待講演)